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Vascular morphogenesis comprises embryonic vasculogenesis and angiogenesis that occurs during fetal development, as well as cyclic renewal and repair in the adult. Recent studies, including those of knockout mice, have led to a coherent picture of the molecular mechanisms regulating these phenomena, that have indicated new approaches to the therapy of angiogenesis-related diseases, such as cancer. This book is the concerted effort of an outstanding cast of multidisciplinary contributors who attempt to convey the current level of understanding of vascular morphogenesis. Such an effort is characteristic of a new era in biology which makes productive connections among classical developmental biology, molecular biology and computer modeling. Each of the three editors emphasizes these connections in the introductions to the three parts of this book. Detailed assays enhance the practical value of the volume for specialists and beginners alike. The book is highly recommended for researchers interested in how vessels are built, both in nature and via modeling. Students in a broad array of fields-biology, medicine, biomedical engineering, biophysics-will find this volume inspiring. The book also serves as an introduction to the field for computer specialists seeking new and exciting applications to computer modeling. Series: Cardiovascular Molecular Morphogenesis Contents: List of Contributors Foreword J. Folkman Series Preface R.R. Markwald Part I: Vascular Morphogenesis In Vivo Introduction by C.D. Little 1.1 The Morphogenesis of Primordial Vascular Networks C. Drake and C. Little 1.2 ngiogenesis and Lymphoangiogenesis: Analogous Mechanisms and Homologous Growth Factors J. Wilting, H. Kurz, S. Oh, B.Christ 1.3 Ontogeny of the Endothelial Network Analyzed in the Avian Model F. Dieterlen-Lievre and L. Pardanaud 1.4 Methodology for the Study of Vascular Morphogenesis in vivo M. DeRuiter, R. Poelmann and A. Gittenberger-de Groot 1.5 Growth Factors in Vascular Morphogenesis: Insights from Gene Knockout Studies in Mice C. Suri and G. Yancopoulos Part II: Vascular Morphogenesis In Vitro Introduction by E.H. Sage 2.1 Three-Dimensional In Vitro Assay of Endothelial Cell Invasion and Capillary Tube Morphogenesis R. Montesano and M. Pepper 2.2 The Rat Aorta Model of Angiogenesis and its Applications R. Nicosia 2.3 In Vitro Models of Blood Vessel Assembly P. D’Amore and K. Hirschi Part III: Vascular Morphogenesis in Mente Introduction by V.A. Mironov 3.1 Models for the Formation of Net-like Structures H. Meinhardt 3.2 Mathematical Model of Vascular Morphogenesis: Role of Mechanical Factors J. Murray, D. Manoussaki, S. Lubkin, R. Vernon 3.3 Blood Vessel Growth: Mathematical Analysis and Computer Simulation, Fractality and Optimality H.Kurz, K.Sandau, J.Wilting, B.Christ 3.4 Mathematical Modeling of Tumor-Induced Angiogenesis M. Chaplain and M. Orrne 3.5 Is the Fractal Nature of Intraorgan Spatial Flow Distributions Based on Vascular Network Growth or on Local Metabolic Needs? J.B. Bassinghwaighte, D. Beard, Z. Li, and T. Yipintsoi
Autor: Little, C.