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This is the first book which deals in a comprehensive manner with two different recent developments with hematopoietic stem cells. The first is their retrieval from cord blood as an alternative to bone marrow. Since this approach was first suggested 10 years ago, there has been worldwide activity to establish cord blood banks, and more than 10 000 samples have been entered and 1000 transplanted in one center alone. The second application of hematopoietic stem cells is therapy in utero, e.g., of inborn errors of metabolism The first successful treatment of effective severe combined immunodeficiency in utero have been reported, though many problems remain to be solved.