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This book is unique for its comprehensive presentation of protease function in stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data.