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The book focuses on drug discovery for psychiatric and neurological diseases, which is in a phase of explosive growth. Chapters are divided into two major sections. The first section presents fundamentals of drug discovery, highlighting the modern techniques and approaches of drug discovery in biotech and pharmaceutical companies. Specific aspects of brain diseases, such penetration of the blood-brain barrier, are addressed. The author pays particular attention to clinical proof-of-concept research. Discussion of drug discovery for the major nervous system diseases represents the second section of the book. Each chapter looks at a particular class of disease, beginning with a summary of current understanding of disease mechanism and treatment, followed by thorough discussion of novel targets and emerging drugs.