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The book begins by covering the natural history and progress of the menopause and aspects of the current practice of climacteric medicine, and then moves on to the issues of quality of life, currently utilized hormone preparations, the problems of the recent larger trials and epidemiology. The last section includes the Position Statements generated by various Regional Societies and provides a vision of the needs for future research in climacteric medicine. Reviewing the biological and practical rationale of all existing HRT agents, the book provides a re-evaluation of these agents with the goal of the development of a consensus for climacteric medicine world-wide. Readers can then use this information to determine an individual woman’s risk profile and properly assess the potential of therapeutic intervention.