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Bioelectrochemistry: Principles and Practice provides a comprehensive compilation of all the physicochemical aspects of the different biochemical and physiological processes. Macromolecules, essentially nucleic acids, proteins, and complex carbohydrates, are the building blocks of cell structures and function. This fifth volume in the Bioelectrochemistry series deals essentially with water-soluble biomacromolecules, since the properties of membrane-bound proteins are considered in other volumes. The first chapter provides and extensive review of the structure, chemical reactivity and electromagnetic properties of nucleic acids. The following five chapters concentrate on proteins, their structure, folding and function. Particular emphasis is placed on the electrochemistry of redox proteins and the voltammetric methods used to investigate these properties are reviewed. Special attention is devoted to the field of thiol/disulfide exchange as well as to one particular class of proteins, the iron-sulfur proteins. The last chapter considers the chemistry and properties of glycosaminoglycans, the complex charged polysaccharides of the cell surface and extracellular matrix. The series is intended as a set of source books for graduate and postgraduate students as well as research workers at all levels in bioelectrochemistry. Series: Bioelectrochemistry: Principles and Practice, Volume 5 Contents: Dedication List of Contributors Introduction 1. Structure, chemical reactivity and electromagnetic properties of nucleic acids/V. Brabec, V. Kleinwachter and V. Vetterl Introduction Nucleic acid structure Chemical reactivity of nucleic acids Electric and magnetic properties of nucleic acids 2. Proteins: Structure, folding and function/D. W. Urry, and C.-H. Luan Introduction Protein structure Inverse temperature transitions (cold denaturation) in polypeptides and proteins Changing the temperature, Tt, of the inverse temperature transition for folding and assembly Development of macroscopic assay system for observing the folding and assembly transition and its equivalent of energy conversion The Delta Tt-mechanism for energy conversion in polypeptides and proteins The Delta Tt hydrophobic paradigm for protein folding and function Concluding comment 3. Electrochemistry of redox proteins/H. A. O. Hill, C. B. Moore and D. M. A. NabiRahni Introduction Protein electrochemistry The nature of the electrode surface STM and AFM of electrode surfaces The microscopic model Protein-protein complexes Direct enzyme electrochemistry Biosensors Conclusions 4. Applications of voltammetric methods for probing the chemistry of redox proteins/F. A. Armstrong Introduction Voltammetric methods for studying redox proteins Applications to studies of redox-active sites in proteins Concluding remarks 5. Thiol/disulfide exchange and redox potentials of proteins/H. F. Gilbert Introduction Equilibrium behavior of thiol/disulfides in a redox barrier Measuring thiol/disulfide oxidation potentials Studies with small molecules Factors affecting protein thiol/disulfide oxidation potentials Thiol/disulfide interconversions during enzyme catalysis Thiol/disulfides as redox carriers Role of oxidation potential of a dithiol in protein folding Proteins in which a disulfide bond stabilizes structure Redox active thiol/disulfides which affect activity Catalysis of thiol/disulfide exchange Conclusions 6. Electrochemistry of iron-sulfur proteins/B. A. Feinberg and M. D. Ryan Introduction to iron-sulfur proteins Electrochemical techniques Voltammetric studies of iron-sulfur proteins Conclusions 7. Glycosaminoglycans: Sulphated polysaccharides of the cell surface and extracellular mix/D. A. Pye Introduction Glycosaminoglycan biosynthesis Glycosaminoglycan interactions Glycosaminoglycan sequencing Clinical application of glycosaminoglycans Index